Urs Eiholzer from the Centre for Paediatric Endocrinology, Zurich and member of our Clinical and Scientific Advisory Board tells us more about the latest research into PWS and Hypogonadism:
Although hypogonadism is prevalent in males and females with PWS, knowledge about this condition is limited and there are no clear guidelines for diagnosis and treatment.
In particular, gonadal hormone substitution is a matter of debate due to concerns associated with the potentially induced aggressive behaviour, foremost in males, which may be caused by sex steroids.
In our two recently published papers, we outline the current knowledge on the clinical, biochemical, genetic and histological features of hypogonadism in PWS and its treatment. This is based on current literature and the outcomes of a specially designed questionnaire, where we assessed “the current standard of care” of hypogonadism in children and adults with PWS, in collaboration with the IPWSO international conference held in November 2019 in Cuba.
Gonadal Hormone Substitution in People with Prader-Labhart-Willi Syndrome: An International Prader-Willi Syndrome Organisation Survey; Urs Eiholzer et al.; Hormone Research in Paediatrics
Prader–Willi Syndrome and Hypogonadism: A Review Article, Urs Eiholzer et al; International Journal of Molecular Sciences
Please do get in touch if you would like to read the full papers.